PaReBrick: PArallel REarrangements and BReaks identification toolkit.

ABSTRACT:

Motivation

High plasticity of bacterial genomes is provided by numerous mechanisms including horizontal gene transfer and recombination via numerous flanking repeats. Genome rearrangements such as inversions, deletions, insertions and duplications may independently occur in different strains, providing parallel adaptation or phenotypic diversity. Specifically, such rearrangements might be responsible for virulence, antibiotic resistance and antigenic variation. However, identification of such events requires laborious manual inspection and verification of phyletic pattern consistency.

Results

Here, we define the term 'parallel rearrangements' as events that occur independently in phylogenetically distant bacterial strains and present a formalization of the problem of paralle

SUBMITTER: Zabelkin A 

PROVIDER: S-EPMC8723149 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature