Cigarette Smoke Exposure Inhibits Osteoclast Apoptosis via the mtROS Pathway.

ABSTRACT: It is widely known that smoking is a risk factor for bone loss and plays a key role in osteopenia. Despite this well-known association, the mechanisms by which smoking affects bone have not been definitively established. Since smoking increases bone loss and potentially affects bone resorption in response to mechanical force, we investigated the impact of cigarette smoke on osteoclast numbers and underlying mechanisms in a mouse model of orthodontic tooth movement (OTM). The experimental group was exposed to once-daily cigarette smoke while the control group was not, and tooth movement distance and osteoclast numbers were assessed. In addition, the effect of cigarette smoke extract (CSE) on osteoclast precursor proliferation and osteoclast apoptosis was assessed in vitro. We found that cig

SUBMITTER: Qin Y 

PROVIDER: S-EPMC8723169 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature