ABSTRACT: Due to the spreading of the coronavirus (COVID-19) in Iran, restrictions and lockdown were announced to control the infection. In order to determine the effects of the lockdown period on the status of the water quality and pollution, the concentrations of Al, As, Ba, Cr, Cu, Mo, Ni, Pb, Se, and Zn, together with Na+, Mg2+, Ca2+ and electrical conductivity (EC), were measured in the Zarjoub River, north of Iran, in both pre-lockdown and post-lockdown periods. The results indicated that water pollution and associated human health risk reduced by an average of 30% and 39%, respectively, during the lockdown period. In addition, the multi-purpose water quality index also improved by an average of 34%. However, the water salinity and alkalinity increased during t