Heightened splenic and bone marrow uptake of ¹⁸F-FDG PET/CT is associated with systemic inflammation and subclinical atherosclerosis by CCTA in psoriasis: An observational study.

ABSTRACT:

Background and aims

Psoriasis is an immune-mediated inflammatory disease with increased risk of myocardial infarction. Preclinical studies in psoriasis models show an association between chronic inflammation and immune cell proliferation in the spleen and bone marrow (BM). We sought to test the hypothesis that splenic and BM ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake is heightened in psoriasis and that higher uptake associates with systemic inflammation and subclinical atherosclerotic disease measures in this cohort.

Methods

Multimodality imaging and biomarker assays were performed in 240 participants (210 with psoriasis and 30 healthy). Splenic and BM uptake was obtained using ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT). C

SUBMITTER: Patel NH 

PROVIDER: S-EPMC8723715 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature