The Determinants of B Cell Receptor Signaling as Prototype Molecular Biomarkers of Leukemia.

ABSTRACT: Advanced genome-wide association studies (GWAS) identified several transforming mutations in susceptible loci which are recognized as valuable prognostic markers in chronic lymphocytic leukemia (CLL) and B cell lymphoma (BCL). Alongside, robust genetic manipulations facilitated the generation of preclinical mouse models to validate mutations associated with poor prognosis and refractory B cell malignancies. Taken together, these studies identified new prognostic markers that could achieve characteristics of precision biomarkers for molecular diagnosis. On the contrary, the idea of augmented B cell antigen receptor (BCR) signaling as a transforming cue has somewhat receded despite the efficacy of Btk and Syk inhibitors. Recent studies from several research groups pointed out that acquired m

SUBMITTER: Nicolo A 

PROVIDER: S-EPMC8724047 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature