Models and methods to characterise levonorgestrel release from intradermally administered contraceptives.

ABSTRACT: Microneedle (MN)-based technologies have been proposed as a means to facilitate minimally invasive sustained delivery of long-acting hormonal contraceptives into the skin. Intradermal administration is a new route of delivery for these contraceptives and therefore no established laboratory methods or experimental models are available to predict dermal drug release and pharmacokinetics from candidate MN formulations. This study evaluates an in vitro release (IVR) medium and a medium supplemented with ex vivo human skin homogenate (SH) as potential laboratory models to investigate the dermal release characteristics of one such hormonal contraceptive that is being tested for MN delivery, levonorgestrel (LNG), and provides details of an accompanying novel two-step liquid-liquid drug extraction

SUBMITTER: Al Dalaty A 

PROVIDER: S-EPMC8724103 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature