Sustainable mechanochemical synthesis of β-cyclodextrin polymers by twin screw extrusion.

ABSTRACT: Cyclodextrin nanosponges (CD-NS) are cross-linked cyclodextrin polymers characterized by a nanostructured three-dimensional network. CD-NSs in the last years found many different applications in the pharmaceutical field for the controlled release of drugs and for the absorption of undesired substances from physiological media, food, and wastewater. Most of CD-NS syntheses involve the solubilization of the chosen CD in closed batch, using a suitable organic polar aprotic liquid, which may affect potential environmental or biomedical applications. Since the research is now moving towards more sustainable approaches, new and greener syntheses of CD-NS are now being developed. Here, it is reported a new eco-friendly and efficient synthesis of nanosponges through mechanochemistry. Mechanochemis

SUBMITTER: Rubin Pedrazzo A 

PROVIDER: S-EPMC8724137 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature