MR imaging characteristics of uveal melanoma with histopathological validation.

ABSTRACT:

Purpose

To evaluate the magnetic resonance imaging (MRI) characteristics of uveal melanoma (UM), to compare them with fundoscopy and ultrasound (US), and to validate them with histopathology.

Methods

MR images from 42 UM were compared with US and fundoscopy, and on 14 enucleated cases with histopathology.

Results

A significant relationship between the signal intensity on T1 and pigmentation on histopathology was found (p=0.024). T1 hyperintense UM were always moderately or strongly pigmented on histopathology, while T1-hypointense UM were either pigmented or non-pigmented. Mean apparent diffusion coefficient (ADC) of the UM was 1.16 ± 0.26 × 10^-3 mm²/s. Two-thirds of the UM had a wash-out and the remaining a plateau perfusion time-intensity curve

SUBMITTER: Ferreira TA 

PROVIDER: S-EPMC8724164 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature