Patient-Related Prognostic Factors for Anastomotic Leakage, Major Complications, and Short-Term Mortality Following Esophagectomy for Cancer: A Systematic Review and Meta-Analyses.

ABSTRACT:

Objective

The aim of this study is to identify preoperative patient-related prognostic factors for anastomotic leakage, mortality, and major complications in patients undergoing oncological esophagectomy.

Background

Esophagectomy is a high-risk procedure with an incidence of major complications around 25% and short-term mortality around 4%.

Methods

We systematically searched the Medline and Embase databases for studies investigating the associations between patient-related prognostic factors and anastomotic leakage, major postoperative complications (Clavien-Dindo ≥ IIIa), and/or 30-day/in-hospital mortality after esophagectomy for cancer.

Results

Thirty-nine eligible studies identifying 37 prognostic factors were included. Cardiac comorbidity was associated wi

SUBMITTER: van Kooten RT 

PROVIDER: S-EPMC8724192 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature