Clinical Relevance of Gastroesophageal Cancer Associated SNPs for Oncologic Outcome After Curative Surgery.

ABSTRACT:

Background

Gastric and esophageal cancers are malignant diseases with rising importance in Western countries. To improve oncologic outcome after surgery, it is essential to understand the relevance of germline mutations. The aim of the study was to identify and distinguish clinically relevant single-nucleotide polymorphisms (SNPs).

Patients and methods

In total, 190 patients with curative oncological resections of gastric and distal esophageal adenocarcinomas at Heidelberg University Hospital were eligible for this study. Outcome differences were determined for each SNP by analysis of clinical variables, survival, and mRNA expression levels.

Results

Significant survival differences were found on univariate analysis for usual prognostic variables (such as pTNM) and for

SUBMITTER: Jung JO 

PROVIDER: S-EPMC8724221 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature