N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice.

ABSTRACT: N-n-Butyl haloperidol iodide (F₂) is a novel compound that has antiproliferative and antifibrogenic activities. In this study we investigated the therapeutic potential of F₂ against liver fibrosis in mice and the underlying mechanisms. Two widely used mouse models of fibrosis was established in mice by injection of either carbon tetrachloride (CCl₄) or thioacetamide (TAA). The mice received F₂ (0.75, 1.5 or 3 mg·kg^-1·d^-1, ip) for 4 weeks of fibrosis induction. We showed that F₂ administration dose-dependently ameliorated CCl₄- or TAA-induced liver fibrosis, evidenced by significant decreases in collagen deposition and c-Jun, TGF-β receptor II (TGFBR2), α-smooth muscle actin (α-SMA), and collagen I expre

SUBMITTER: Shen DF 

PROVIDER: S-EPMC8724321 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature