Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound.

ABSTRACT: Brain tumors are particularly challenging malignancies, due to their location in a structurally and functionally distinct part of the human body - the central nervous system (CNS). The CNS is separated and protected by a unique system of brain and blood vessel cells which together prevent most bloodborne therapeutics from entering the brain tumor microenvironment (TME). Recently, great strides have been made through microbubble (MB) ultrasound contrast agents in conjunction with ultrasound energy to locally increase the permeability of brain vessels and modulate the brain TME. As we elaborate in this review, this physical method can effectively deliver a wide range of anticancer agents, including chemotherapeutics, antibodies, and nanoparticle drug conjugates across a range of preclinical

SUBMITTER: Schoen S 

PROVIDER: S-EPMC8724442 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature