Droplet microfluidic devices for organized stem cell differentiation into germ cells: capabilities and challenges.

ABSTRACT: Demystifying the mechanisms that underlie germline development and gamete production is critical for expanding advanced therapies for infertile couples who cannot benefit from current infertility treatments. However, the low number of germ cells, particularly in the early stages of development, represents a serious challenge in obtaining sufficient materials required for research purposes. In this regard, pluripotent stem cells (PSCs) have provided an opportunity for producing an unlimited source of germ cells in vitro. Achieving this ambition is highly dependent on accurate stem cell niche reconstitution which is achievable through applying advanced cell engineering approaches. Recently, hydrogel microparticles (HMPs), as either microcarriers or microcapsules, have shown promising potenti

SUBMITTER: Hayaei Tehrani RS 

PROVIDER: S-EPMC8724463 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature