Clinical Importance of Left Atrial Infiltration in Cardiac Transthyretin Amyloidosis.

ABSTRACT:

Objectives

The aim of this study was to characterize left atrial (LA) pathology in explanted hearts with transthyretin amyloid cardiomyopathy (ATTR-CM); LA mechanics using echocardiographic speckle-tracking in a large cohort of patients with ATTR-CM; and to study the association with mortality.

Background

The clinical significance of LA involvement in ATTR-CM is of great clinical interest.

Methods

Congo red staining and immunohistochemistry was performed to assess the presence, type, and extent of amyloid and associated changes in 5 explanted ATTR-CM atria. Echo speckle tracking was used to assess LA reservoir, conduit, contractile function, and stiffness in 906 patients with ATTR-CM (551 wild-type (wt)-ATTR-CM; 93 T60A-ATTR-CM; 241 V122I-ATTR-CM; 21 other).

Result

SUBMITTER: Bandera F 

PROVIDER: S-EPMC8724534 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature