MiRNA Combinatorics and its Role in Cell State Control-A Probabilistic Approach.

ABSTRACT: A hallmark of cancer evolution is that the tumor may change its cell identity and improve its survival and fitness. Drastic change in microRNA (miRNA) composition and quantities accompany such dynamic processes. Cancer samples are composed of cells' mixtures of varying stages of cancerous progress. Therefore, cell-specific molecular profiling represents cellular averaging. In this study, we consider the degree to which altering miRNAs composition shifts cell behavior. We used COMICS, an iterative framework that simulates the stochastic events of miRNA-mRNA pairing, using a probabilistic approach. COMICS simulates the likelihood that cells change their transcriptome following many iterations (100 k). Results of COMICS from the human cell line (HeLa) confirmed that most genes are resistant t

SUBMITTER: Mahlab-Aviv S 

PROVIDER: S-EPMC8724548 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature