Food-Derived High Arginine Peptides Promote Spermatogenesis Recovery in Busulfan Treated Mice.

ABSTRACT: Food-derived peptides with high arginine content have important applications in medicine and food industries, but their potential application in the treatment of oligoasthenospermia remains elusive. Here, we report that high-arginine peptides, such as Oyster peptides and Perilla purple peptides were able to promote spermatogenesis recovery in busulfan-treated mice. We found that both Opp and Ppp could increase sperm concentration and motility after busulfan-induced testicular damage in mice. Further research revealed that Opp and Ppp might promote spermatogonia proliferation, which improved blood-testis barrier recovery between Sertoli cells. Taken together, these high-arginine peptides might be used as a medication or therapeutic component of a diet prescription to improve the fertility o

SUBMITTER: Liu W 

PROVIDER: S-EPMC8724571 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature