Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction.

ABSTRACT: In the drug therapy of tumor, efficient and stable drug screening platforms are required since the drug efficacy varies individually. Here, inspired by the microstructures of hepatic lobules, in which hepatocytes obtain nutrients from both capillary vessel and the central vein, we present a novel hierarchical hydrogel system with ordered micro-nano structure for liver cancer-on-a-chip construction and drug screening. The hierarchical hydrogel system was fabricated by using pregel to fill and replicate self-assembled colloidal crystal arrays and microcolumn array template. Due to the synergistic effect of its interconnected micro-nano structures, the resultant system could not only precisely control the size of cell spheroids but also realize adequate nutrient supply of cell spheroids. We h

SUBMITTER: Zhu L 

PROVIDER: S-EPMC8724685 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature