Review of novel therapeutics in cardiac arrest (ReNTICA): systematic review protocol.

ABSTRACT:

Introduction

Cardiac arrest remains a common and devastating cause of death and disability worldwide. While targeted temperature management has become standard of care to improve functional neurologic outcome, few pharmacologic interventions have shown similar promise.

Methods/analysis

This systematic review will focus on prospective human studies from 2015 to 2020 available in PubMed, Web of Science and EMBASE with a primary focus on impact on functional neurologic outcome. Prospective studies that include pharmacologic agents given during or after cardiac arrest will be included. Study selection will be in keeping with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. If sufficient data involving a given agent are available, a meta-analysis wil

SUBMITTER: Murphy TW 

PROVIDER: S-EPMC8724734 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature