Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them.

ABSTRACT:

Background

Anxiety disorders are the most prevalent mental illnesses in the U.S. and are estimated to consume one-third of the country's mental health treatment cost. Although anxiolytic therapies are available, many patients still exhibit treatment resistance, relapse, or substantial side effects. Further, due to the COVID-19 pandemic and stay-at-home order, social isolation, fear of the pandemic, and unprecedented times, the incidence of anxiety has dramatically increased. Previously, we have demonstrated dihydromyricetin (DHM), the major bioactive flavonoid extracted from Ampelopsis grossedentata, exhibits anxiolytic properties in a mouse model of social isolation-induced anxiety. Because GABAergic transmission modulates the immune system in addition to the inhibitory signal tra

SUBMITTER: Al Omran AJ 

PROVIDER: S-EPMC8724741 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature