Plasma concentration guided dosing of drugs used for the treatment of childhood leukaemias: protocol for a systematic review.

ABSTRACT:

Introduction

Childhood leukaemia is the most common type of cancer in children and represents among 25% of the diagnoses in children <15 years old. Childhood survival rates have significantly improved within the last 40 years due to a rapid advancement in therapeutic interventions. However, in high-risk groups, survival rates remain poor. Pharmacokinetic (PK) data of cancer medications in children are limited and thus current dosing regimens are based on studies with small sample sizes. In adults, large variability in PK is observed and dose individualisation (plasma concentration guided dosing) has been associated with improved clinical outcomes; whether this is true for children is still unknown. This provides an opportunity to explore this strategy in children to potentially red

SUBMITTER: van Dyk M 

PROVIDER: S-EPMC8724759 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature