Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial.

ABSTRACT:

Objective

To investigate the effects of one and two doses of intravenous dexamethasone in patients after total knee arthroplasty.

Design

Randomised, blinded, placebo controlled trial with follow-up at 90 days.

Setting

Five Danish hospitals, September 2018 to March 2020.

Participants

485 adult participants undergoing total knee arthroplasty.

Intervention

A computer generated randomised sequence stratified for site was used to allocate participants to one of three groups: DX1 (dexamethasone (24 mg)+placebo); DX2 (dexamethasone (24 mg)+dexamethasone (24 mg)); or placebo (placebo+placebo). The intervention was given preoperatively and after 24 hours. Participants, investigators, and outcome assessors were blinded. All participants received paracetamol, ibupr

SUBMITTER: Gasbjerg KS 

PROVIDER: S-EPMC8724786 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature