A Prospective, Randomized, Double-Blind Study to Evaluate the Safety, Biodistribution, and Dosimetry of ⁶⁸Ga-NODAGA-LM3 and ⁶⁸Ga-DOTA-LM3 in Patients with Well-Differentiated Neuroendocrine Tumors.

ABSTRACT: ⁶⁸Ga-NODAGA-LM3 (where LM3 is p-Cl-Phe-cyclo(d-Cys-Tyr-d-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)d-Tyr-NH₂) and ⁶⁸Ga-DOTA-LM3 are somatostatin receptor subtype 2 (SSTR2)-specific antagonists used for PET/CT imaging. The purpose of this study was to evaluate the safety, biodistribution, and dosimetry of ⁶⁸Ga-NODAGA-LM3 and ⁶⁸Ga-DOTA-LM3 in patients with well-differentiated neuroendocrine tumors. Methods: Patients were equally randomized into 2 arms, with arm A receiving ⁶⁸Ga-NODAGA-LM3 and arm B receiving ⁶⁸Ga-DOTA-LM3. Serial PET scans were acquired at 5, 15, 30, 45, 60, and 120 min after ⁶⁸Ga-NODAGA-LM3 (200 MBq ± 11 MBq/40 μg of total peptide mass) or ⁶⁸Ga-DOTA-LM3 (172 MBq ± 21 MB

SUBMITTER: Zhu W 

PROVIDER: S-EPMC8724897 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature