Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, ¹⁸F-FMISO PET, and ¹⁸F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma.

ABSTRACT: Conventional MRI plays a key role in the management of patients with high-grade glioma, but multiparametric MRI and PET tracers could provide further information to better characterize tumor metabolism and heterogeneity by identifying regions having a high risk of recurrence. In this study, we focused on proliferation, hypervascularization, and hypoxia, all factors considered indicative of poor prognosis. They were assessed by measuring uptake of ¹⁸F-3'-deoxy-3'-¹⁸F-fluorothymidine (¹⁸F-FLT), relative cerebral blood volume (rCBV) maps, and uptake of ¹⁸F-fluoromisonidazole (¹⁸F-FMISO), respectively. For each modality, the volumes and high-uptake subvolumes (hot spots) were semiautomatically segmented and compared with the contrast enhan

SUBMITTER: Collet S 

PROVIDER: S-EPMC8724903 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature