The Effect of Interferons on Presentation of Defective Ribosomal Products as HLA Peptides.

ABSTRACT: A subset of class I major histocompatibility complex (MHC)-bound peptides is produced from immature proteins that are rapidly degraded after synthesis. These defective ribosomal products (DRiPs) have been implicated in early alert of the immune system about impending infections. Interferons are important cytokines, produced in response to viral infection, that modulate cellular metabolism and gene expression patterns, increase the presentation of MHC molecules, and induce rapid degradation of proteins and cell-surface presentation of their derived MHC peptides, thereby contributing to the battle against pathogen infections. This study evaluated the role of interferons in the induction of rapid degradation of DRiPs to modulate the repertoire of DRiP-derived MHC peptides. Cultured human brea

SUBMITTER: Komov L 

PROVIDER: S-EPMC8724922 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature