Therapeutic exosomal vaccine for enhanced cancer immunotherapy by mediating tumor microenvironment.

ABSTRACT: Tumor immunotherapy has been convincingly demonstrated as a feasible approach for treating cancers. Although promising, the immunosuppressive tumor microenvironment (TME) has been recognized as a major obstacle in tumor immunotherapy. It is highly desirable to release an immunosuppressive "brake" for improving cancer immunotherapy. Among tumor-infiltrated immune cells, tumor-associated macrophages (TAMs) play an important role in the growth, invasion, and metastasis of tumors. The polarization of TAMs (M2) into the M1 type can alleviate the immunosuppression of the TME and enhance the effect of immunotherapy. Inspired by this, we constructed a therapeutic exosomal vaccine from antigen-stimulated M1-type macrophages (M1_OVA-Exos). M1_OVA-Exos are capable of polarizing TA

SUBMITTER: Lv F 

PROVIDER: S-EPMC8724970 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature