Ontology highlight
ABSTRACT:
SUBMITTER: Marty FH
PROVIDER: S-EPMC8724971 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Marty Florent Henri FH Bettamin Luca L Thouard Anne A Bourgade Karine K Allart Sophie S Larrieu Guilhem G Malnou Cécile Evelyne CE Gonzalez-Dunia Daniel D Suberbielle Elsa E
iScience 20211216 1
Borna disease viruses (BoDV) have recently emerged as zoonotic neurotropic pathogens. These persistent RNA viruses assemble nuclear replication centers (vSPOT) in close interaction with the host chromatin. However, the topology of this interaction and its consequences on neuronal function remain unexplored. In neurons, DNA double-strand breaks (DSB) have been identified as novel epigenetic mechanisms regulating neurotransmission and cognition. Activity-dependent DSB contribute critically to neur ...[more]