Bidirectional relationship between cardiac extracellular matrix and cardiac cells in ischemic heart disease.

ABSTRACT: Ischemic heart diseases (IHDs), including myocardial infarction and cardiomyopathies, are a leading cause of mortality and morbidity worldwide. Cardiac-derived stem and progenitor cells have shown promise as a therapeutic for IHD but are limited by poor cell survival, limited retention, and rapid washout. One mechanism to address this is to encapsulate the cells in a matrix or three-dimensional construct, so as to provide structural support and better mimic the cells' physiological microenvironment during administration. More specifically, the extracellular matrix (ECM), the native cellular support network, has been a strong candidate for this purpose. Moreover, there is a strong consensus that the ECM and its residing cells, including cardiac stem cells, have a constant interplay in respo

SUBMITTER: Park HJ 

PROVIDER: S-EPMC8725061 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature