Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines.

ABSTRACT: Landmark successes in oncoimmunology have led to development of therapeutics boosting the host immune system to eradicate local and distant tumors with impactful tumor reduction in a subset of patients. However, current immunotherapy modalities often demonstrate limited success when involving immunologically cold tumors and solid tumors. Here, we describe the role of various biomaterials to formulate cancer vaccines as a form of cancer immunotherapy, seeking to utilize the host immune system to activate and expand tumor-specific T cells. Biomaterial-based cancer vaccines enhance the cancer-immunity cycle by harnessing cellular recruitment and activation against tumor-specific antigens. In this review, we discuss biomaterial-based vaccine strategies to induce lymphocytic responses necessary

SUBMITTER: Viswanath DI 

PROVIDER: S-EPMC8725170 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature