A nano based approach to alleviate cisplatin induced nephrotoxicity.

ABSTRACT:

Background and objective

Cisplatin, an effective drug against cancer, commonly induces nephrotoxicity; limiting its therapeutic efficacy and application. In this study, Cisplatin NanoComposite (Cis NC) was formulated successfully from irradiated chitosan coated Cisplatin and MgO nanoparticles (CHIT/Cis/MgO NPs) to promote cisplatin release in a more sustained manner to improve therapeutic efficacy via the reduction of its nephrotoxicity. To compare the relative induced renal toxicity of cisplatin with Cisplatin NanoComposite, histological and biochemical mechanisms underlying nephrotoxicity were investigated.

Methods

Thirty rats were equally separated to three groups, first group received saline injections and adjusted as the control group, the second group was injected intr

SUBMITTER: Anees LM 

PROVIDER: S-EPMC8725228 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature