Mn doped Prussian blue nanoparticles for T₁/T₂ MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor.

ABSTRACT:

Background

Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy.

Results

In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T₁ and T₂ weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature phototherma

SUBMITTER: Tao Q 

PROVIDER: S-EPMC8725273 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature