Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.

ABSTRACT:

Background

Fatty acids play prominent roles in brain function as they participate in structural, metabolic and signaling processes. The homeostasis of fatty acids and related pathways is known to be impaired in cognitive decline and dementia, but the relationship between these metabolic disturbances and common risk factors, namely the ɛ4 allele of the apolipoprotein E (ApoE-ɛ4) gene and sex, remains elusive.

Methods

In order to investigate early alterations associated with cognitive decline in the fatty acid-related serum metabolome, we here applied targeted metabolomics analysis on a nested case-control study (N=368), part of a prospective population cohort on dementia.

Results

When considering the entire study population, circulating levels of free fatty acids, acyl

SUBMITTER: Gonzalez-Dominguez R 

PROVIDER: S-EPMC8725342 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature