Ontogeny of RORγt⁺ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis.

ABSTRACT:

Background

Neonates possess an immature and plastic immune system, which is a major cause of some diseases in newborns. Necrotizing enterocolitis (NEC) is a severe and devastating intestinal disease that typically affects premature infants. However, the development of intestinal immune cells in neonates and their roles in the pathological process of NEC have not been elucidated.

Results

We examined the ontogeny of intestinal lamina propria lymphocytes in the early life of mice and found a high percentage of RORγt⁺ cells (containing inflammatory Th17 and ILC3 populations) during the first week of life. Importantly, the proportion of RORγt⁺ cells of intestinal lamina propria further increased in both NEC mice and patients tissue than the control. Furtherm

SUBMITTER: Zhao X 

PROVIDER: S-EPMC8725364 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature