The association of zonulin-related proteins with prevalent and incident inflammatory bowel disease.

ABSTRACT:

Background

Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of incident IBD is still unexplored. This study aimed to investigate the association of serum ZRP levels with both prevalent and incident IBD.

Method

The study included a total of 130 women (51-61 years) from the Women's Health in Lund Area (WHILA) study, which included 18 prevalent IBD (diagnosed before baseline) and 47 incident IBD diagnosed during the 17 years (median) follow-up and age- and sampling time-matched controls. Serum ZRP was tested in all participants by ELISA.

Results

The serum ZRP levels were significantly higher in prevalent IBD compare

SUBMITTER: Wang X 

PROVIDER: S-EPMC8725386 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature