Repurposing a clinically approved prescription Colquhounia root tablet to treat diabetic kidney disease via suppressing PI3K/AKT/NF-kB activation.

ABSTRACT:

Background

Growing clinical evidences show the potentials of Colquhounia root tablet (CRT) in alleviating diabetic kidney disease (DKD). However, its pharmacological properties and underlying mechanisms remain unclear.

Methods

'Drug target-Disease gene' interaction network was constructed and the candidate network targets were screened through evaluating node genes' topological importance. Then, a DKD rat model induced by high-fat diet/streptozotocin was established and used to determine pharmacological effects and network regulatory mechanisms of CRT against DKD, which were also verified using HK2 cell model induced by high glucose.

Results

The candidate network targets of CRT against DKD were involved into various type II diabetes-related and nephropathy-related pat

SUBMITTER: Ma Z 

PROVIDER: S-EPMC8725443 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature