Environmental spreading of clinically relevant carbapenem-resistant gram-negative bacilli: the occurrence of bla_KPC-or-NDM strains relates to local hospital activities.

ABSTRACT:

Background

Aquatic matrices impacted by sewage may shelter carbapenem-resistant (CR) Gram-negative bacilli (GNB) harboring resistance genes of public health concern. In this study, sewage treatment plants (STPs) servicing well-defined catchment areas were surveyed for the presence of CR-GNB bearing carbapenemase genes (bla_KPC or bla_NDM).

Results

A total of 325 CR-GNB were recovered from raw (RS) and treated (TS) sewage samples as well as from water body spots upstream (UW) and downstream (DW) from STPs. Klebsiella-Enterobacter (KE) group amounted to 116 isolates (35.7%). CR-KE isolates were recovered from TS, DW (35.7%) and RS samples (44.2%) (p = 0.001); but not from UW samples. KE isolates represented 65.8% of all bla_KPC or bla_NDM

SUBMITTER: Pereira AL 

PROVIDER: S-EPMC8725513 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature