Development of a decision flowchart to identify the patients need high-dose vancomycin in early phase of treatment.

ABSTRACT:

Background

The standard dose of vancomycin (VCM, 2 g/day) sometimes fails to achieve therapeutic concentration in patients with normal renal function. In this study, we aimed to identify factors to predict patients who require high-dose vancomycin (> 2 g/day) to achieve a therapeutic concentration and to develop a decision flowchart to select these patients prior to VCM administration.

Methods

Patients who had an estimated creatinine clearance using the Cockcroft-Gault equation (eCCr) of ≥50 mL/min and received intravenous VCM were divided into 2 cohorts: an estimation set (n = 146, from April to September 2016) and a validation set (n = 126, from October 2016 to March 2017). In each set, patients requiring ≤2 g/day of VCM to maintain the therapeutic trough concentration (10

SUBMITTER: Yamaguchi R 

PROVIDER: S-EPMC8725522 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature