Differential Expression of CREM/ICER Isoforms Is Associated with the Spontaneous Control of HIV Infection.

ABSTRACT: A rare subset of HIV-infected individuals, termed elite controllers (ECs), can maintain long-term control over HIV replication in the absence of antiretroviral therapy (ART). To elucidate the biological mechanism of resistance to HIV replication at the molecular and cellular levels, we performed RNA sequencing and identified alternative splicing variants from ECs, HIV-infected individuals undergoing ART, ART-naive HIV-infected individuals, and healthy controls. We identified differential gene expression patterns that are specific to ECs and may influence HIV resistance, including alternative RNA splicing and exon usage variants of the CREM/ICER gene (cyclic AMP [cAMP]-responsive element modulator/inducible cAMP early repressors). The knockout and knockdown of specific ICER exons that were

SUBMITTER: Luo Z 

PROVIDER: S-EPMC8725591 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature