Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure.

ABSTRACT:

Background

Diesel engine exhaust (DEE) exposure causes lung cancer, but the molecular mechanisms by which this occurs are not well understood.

Objectives

To assess transcriptomic alterations in nasal epithelium of DEE-exposed factory workers to better understand the cellular and molecular effects of DEE.

Methods

Nasal epithelial brushings were obtained from 41 diesel engine factory workers exposed to relatively high levels of DEE (17.2-105.4 μg/m³), and 38 unexposed workers from factories without DEE exposure. mRNA was profiled for gene expression using Affymetrix microarrays. Linear modeling was used to identify differentially expressed genes associated with DEE exposure and interaction effects with current smoking status. Pathway enrichment among differen

SUBMITTER: Drizik E 

PROVIDER: S-EPMC8725607 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature