Relationship Between KCNQ1 Polymorphism and Type 2 Diabetes Risk in Northwestern China.

ABSTRACT:

Purpose

This study aimed to explore the relationship between KCNQ1 polymorphism and type 2 diabetes mellitus (T2DM) risk in the population of Northwest China.

Patients and methods

Case-control strategy was used to reveal the correlation between KCNQ1 polymorphism and T2DM risk, and MDR analysis clarified the influence of KCNQ1 polymorphism interaction on T2DM risk. The related proteins, functions, and signal pathways of KCNQ1 were further explored through bioinformatics methods. PCR was used to explore the relative expression of KCNQ1 in T2DM patients and the controls.

Results

Studies showed that rs163177, rs163184, rs2237895 and rs2283228 on the KCNQ1 gene are closely related to the risk of T2DM in Northwest China. MDR results showe

SUBMITTER: Xu J 

PROVIDER: S-EPMC8725845 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature