Host-pathogen interactions upon Candida auris infection: fungal behaviour and immune response in Galleria mellonella.

ABSTRACT: Candida auris has globally emerged as a multidrug-resistant fungus linked to healthcare-associated outbreaks. There is still limited evidence on its virulence, pathogenicity determinants, and complex host-pathogen interactions. This study analyzes the in vivo fungal behaviour, immune response, and host-pathogen interactions upon C. auris infection compared to C. albicans and C. parapsilosis in G. mellonella. This was performed by immunolabelling fungal structures and larval plasmatocytes and using a quantitative approach incorporating bioinformatic morphometric techniques into the study of microbial pathogenesis. C. auris presents a remarkably higher immunogenic activity than expected at its moderate degree of tissue invasion. It induces a g

SUBMITTER: Garcia-Bustos V 

PROVIDER: S-EPMC8725852 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature