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Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime.

ABSTRACT: We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

SUBMITTER: Horvat M

PROVIDER: S-EPMC8725990 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime.

Horvat Melissa M Weilch Victoria V Rädisch Robert R Hecko Sebastian S Schiefer Astrid A Rudroff Florian F Wilding Birgit B Klempier Norbert N Pátek Miroslav M Martínková Ludmila L Winkler Margit M

Catalysis science & technology 20211130 1

We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode. ...[more]

PMID: 35126993

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