The Relationship Between Plasma BDNF and Pain in Older Adults With Knee Osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is the most prevalent cause of chronic pain and disability in people aged ≥45 years, with the knee being the most affected joint. Neurotrophic factors like brain-derived neurotrophic factor (BDNF), which promotes neurogenesis and neuroplasticity, have been shown to significantly affect chronic pain. This study aimed to investigate the relationship between resting plasma BDNF levels and clinical pain and quantitative sensory testing measures in older adults with knee OA pain. For this secondary analysis, a previously reported dataset was used comprised of older adults with knee OA who underwent quantitative sensory testing. A comprehensive generalized linear model (GLM) was built to understand the relationships between BDNF and important covariates, followed by the elast

SUBMITTER: Sorkpor SK 

PROVIDER: S-EPMC8726424 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature