Patterns of relapse following hippocampal avoidance prophylactic cranial irradiation for small cell lung carcinoma.

ABSTRACT:

Background

Hippocampal avoidance techniques are an evolving standard of care for patients undergoing cranial irradiation. Our aim was to assess the oncological outcomes and patterns of failure following hippocampal avoidance prophylactic cranial irradiation (HA-PCI) as a standard of care in unselected patients with both limited and extensive stage small cell lung carcinoma.

Materials and methods

Consecutive patients with small cell lung carcinoma with a complete (limited stage) or good partial (extensive stage) response following chemotherapy were eligible to receive HA-PCI, with a total dose of 25 Gray in 10 fractions. All patients had a negative baseline MRI brain scan with gadolinium prior to HA-PCI. Patients had baseline and follow up Common Toxicity Criteria Adverse Eve

SUBMITTER: Cook TA 

PROVIDER: S-EPMC8726451 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature