Immunological and prognostic significance of novel ferroptosis-related genes in soft tissue sarcoma.

ABSTRACT:

Background

Ferroptosis has exhibited great potential in the treatment of cancer and has gained widespread attention in soft tissue sarcoma (STS). The aim was to explore the immunological and prognostic significance of novel ferroptosis-related genes in STS.

Methods

We identified ferroptosis-related differentially expressed genes (DEGs) in STS to construct the networks of enrichment analysis and protein-protein interaction. Subsequently, hub genes with prognostic significance were localized and a series of prognostic and immune analyses were performed.

Results

40 ferroptosis-related DEGs were identified, of which HELLS, STMN1 EPAS1, CXCL2, NQO1, and IL6 were classified as hub genes and were associated with the prognosis in STS patients. In the results of the immune ana

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8726495 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature