Ibrutinib's off-target mechanism: cause for dose optimization.
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ABSTRACT:
SUBMITTER: Zimmerman SM
PROVIDER: S-EPMC8726609 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Ibrutinib's off-target mechanism: cause for dose optimization.
Zimmerman Sara M SM Peer Cody J CJ Figg William D WD
Cancer biology & therapy 20211010 10-12
Ibrutinib (Imbruvica®, 2013) is a Bruton's tyrosine kinase (BTK) inhibitor approved for multiple B-cell malignancies and cGVHD. Its treatment is associated with increased risk of cardiac adverse events. Atrial fibrillation is a common cause of therapy discontinuation and interruptions, which have been correlated with shorter progression-free survival in chronic lymphocyte leukemia (CLL) patients. Recently, Xiao et al. identified that ibrutinib-mediated atrial fibrillation is likely due to off-ta ...[more]
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