Impact of IgG subclass on molecular properties of monoclonal antibodies.

ABSTRACT: Immunoglobulin G-based monoclonal antibodies (mAbs) have become a dominant class of biotherapeutics in recent decades. Approved antibodies are mainly of the subclasses IgG1, IgG2, and IgG4, as well as their derivatives. Over the decades, the selection of IgG subclass has frequently been based on the needs of Fc gamma receptor engagement and effector functions for the desired mechanism of action, while the effect on drug product developability has been less thoroughly characterized. One of the major reasons is the lack of systematic understanding of the impact of IgG subclass on the molecular properties. Several efforts have been made recently to compare molecular property differences among these IgG subclasses, but the conclusions from these studies are sometimes obscured by the interferen

SUBMITTER: Tang Y 

PROVIDER: S-EPMC8726687 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature