Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism.
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ABSTRACT:
SUBMITTER: Lee TY
PROVIDER: S-EPMC8726689 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism.
Lee Tzu-Yin TY Lu Wan-Jung WJ Changou Chun A CA Hsiung Yuan-Chin YC Trang Nguyen T T NTT Lee Cheng-Yang CY Chang Tzu-Hao TH Jayakumar Thanasekaran T Hsieh Cheng-Ying CY Yang Chih-Hao CH Chang Chao-Chien CC Chen Ray-Jade RJ Sheu Joen-Rong JR Lin Kuan-Hung KH
Autophagy 20210405 12
Basal macroautophagy/autophagy has recently been found in anucleate platelets. Platelet autophagy is involved in platelet activation and thrombus formation. However, the mechanism underlying autophagy in anucleate platelets require further clarification. Our data revealed that LC3-II formation and SQSTM1/p62 degradation were noted in H<sub>2</sub>O<sub>2</sub>-activated human platelets, which could be blocked by 3-methyladenine and bafilomycin A<sub>1</sub>, indicating that platelet activation m ...[more]
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