Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters.

ABSTRACT: Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral infections. We herein hypothesized that disruption of gut homeostasis during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may associate with early disease outcomes. To address this question, we took advantage of the Syrian hamster model. Our data confirmed that this model recapitulates some hallmark features of the human disease in the lungs. We further showed that SARS-CoV-2 infection associated with mild intestinal inflammation, relative alteration in intestinal barrier property and liver inflammation and altered lipid metabolism. These changes occurred concomitantly with an alteration of the gut microbiota composition over the course of infection, notably characterized by

SUBMITTER: Sencio V 

PROVIDER: S-EPMC8726722 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature