Lesion features on magnetic resonance imaging discriminate multiple sclerosis patients.

ABSTRACT:

Background

Magnetic resonance imaging (MRI) provides insight into various pathological processes in multiple sclerosis (MS) and may provide insight into patterns of damage among patients.

Objective

We sought to determine if MRI features have clinical discriminative power among a cohort of MS patients.

Methods

Ninety-six relapsing remitting and seven progressive MS patients underwent myelin water fraction (MWF) imaging and conventional MRI for cortical thickness and thalamic volume. Patients were clustered based on lesion level MRI features using an agglomerative hierarchical clustering algorithm based on principal component analysis (PCA).

Results

One hundred and three patients with 1689 MS lesions were analyzed. PCA on MRI features demonstrated that lesion MWF

SUBMITTER: Hurtado Rua SM 

PROVIDER: S-EPMC8727028 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature