Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice.

ABSTRACT: The importance of a local tissue immune response in healing injured tissues such as skin and lung is well established. Little is known about whether sterile wounds elicit lymph node (LN) responses and inflammatory responses after injury of musculoskeletal tissues that are mechanically loaded during the repair response. We investigated LN and tissue immune responses in a tibial implant model of joint replacement surgery where wounded tissue is subjected to movement and mechanical loading postoperatively. Draining inguinal and iliac LNs expanded postoperatively, including increases in regulatory T cells and activation of a subset of T cells. Thus, tissue injury was actively sensed in secondary lymphoid organs, with the potential to activate adaptive immunity. Joint tissues exhibited three te

SUBMITTER: Xia Y 

PROVIDER: S-EPMC8727029 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature